Candidate and non-candidate genes in behavior genetics
نویسندگان
چکیده
In this review we discuss recent developments in psychiatric genetics: on the one hand, studies using whole genome approaches (genome-wide association studies (GWAS) and exome sequencing) are coming close to finding genes and molecular variants that contribute to disease susceptibility; on the other candidate genes, such as the serotonin transporter, continue to dominate in genetic studies of brain imaging phenotypes and in protracted searches for gene by environment interactions. These two areas intersect, in that new information about genetic effects from whole genome approaches, should (but does not always) inform the single locus analyses.
منابع مشابه
Candidate Gene Polymorphism for IL-Rγ and ChB6 Genes in the Indigenous Chicken of North Western Himalayan State of Himachal Pradesh, India
Present investigation was carried out to identify DNA polymorphism of IL-2Rγ and ChB6 genes. Sixty five birds belonging to the indigenous chicken of Himachal Pradesh were utilized. Good quality DNA samples were subjected to PCR-RFLP analysis using chicken specific primers. Overnight restriction enzyme digestion was carried out at 37°C with IU Hph I and Pvu II for IL-2Rγ and ChB6 genes, respecti...
متن کاملAssociation of Candidate Single Nucleotide Polymorphisms Related to Candidate Genes in Patients With Schizophrenia
Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated with Schizophrenia. The NrCAM contributes to creating cognitive deficiencies through the CAM’s signaling pathway. PRODH plays a vital role in cr...
متن کاملThe Genetics of Non-Syndromic Primary Ovarian Insufficiency: A Systematic Review
Purpose: Several causes for primary ovarian insufficiency have been described, including iatrogenic and environmental factor, viral infections, chronic disease as well as genetic alterations. Given the large number of genes described in the literature so far, the aim of this review was to collect all the genetic mutations associated with non-syndromic primary ovarian insufficiency. Methods: All...
متن کاملEvaluation of the Serotonergic Genes htr1A, htr1B, htr2A, and slc6A4 in Aggressive Behavior of Golden Retriever Dogs
Aggressive behavior displays a high heritability in our study group of Golden Retriever dogs. Alterations in brain serotonin metabolism have been described in aggressive dogs before. Here, we evaluate whether four genes of the canine serotonergic system, coding for the serotonin receptors 1A, 1B, and 2A, and the serotonin transporter, could play a major role in aggression in Golden Retrievers. ...
متن کاملCandidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI.
Before the advent of genome-wide association studies (GWASs), hundreds of candidate genes for obesity-susceptibility had been identified through a variety of approaches. We examined whether those obesity candidate genes are enriched for associations with body mass index (BMI) compared with non-candidate genes by using data from a large-scale GWAS. A thorough literature search identified 547 can...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 23 شماره
صفحات -
تاریخ انتشار 2013